Chinese Color Nest Project

Before we started this project, we were finishing a high-resolution (4mm) network map of the human brain connectome using functional imaging data from more than 1000 healthy adults across different stages of the postnatal lifespan (18-85 years) based upon the 1000 Functional Connectomes Project (Biswal et al., 2010; Zuo et al., 2012). This map was shaped like a colored nest and inspired us to name the project. In addition, color nest represents protection, vitality and development, and implies the concept of respecting individual differences of human beings and promoting healthy development and well-being. CCNP is devoted to collecting data on brain structure and function across different stages of the human lifespan.

This is a twenty-year project, and its long-term goal is to create neurobiologically sound developmental curves for the brain to characterize phenomenological changes associated with the onset of varying forms of mental health and learning disorders, as well as to predict the developmental status (i.e., age-expected values) of an individual brain’s structure or function. Beyond neurodevelopment, lifespan perspectives can help reveal commonalities and differences among pathophysiologic processes that manifest similar symptom profiles at different stages in life. From a neurological perspective, brain maturation and aging curves may prove useful for identifying factors that can mitigate neurocognitive decline and potentially identify optimal periods for intervention. We are seeking knowledge that will translate into a better life style and clinical practice.

CCNP – An Accelerated Design

CCNP takes its first stage during 2013 – 2022 (see a final publication). It aims at establishing protocols on the Chinese normative brain development trajectories across the human lifespan. It implements a structured multi-cohort longitudinal design (or accelerated longitudinal design), which is particularly viable for lifespan trajectory studies, and optimal for recoverable missing data. The CCNP pilot comprises three connected components: developing CCNP (devCCNP, baseline age = 6-18 years, 12 age cohorts, 3 waves, interval = 15 months), maturing CCNP (matCCNP, baseline age = 18-60 years, 14 age cohorts, 3 waves, interval = 39 months) and ageing CCNP (ageCCNP, baseline age = 60-84 years, 12 age cohorts, 3 waves, interval = 27 months).

CCNP – An Accelerated Twins Design

This is the second ten-year phase (twin version) of the CCNP (2021 – 2030), which is designed for building the normative curves on brain development derived from 6000 pairs of twins across the life span (6 – 85 years).

The Chinese Color Nest Consortium

Leadership: Xi-Nian Zuo, Qi Dong (Beijing Normal University)

Sites: Beijing Normal University, Southwest University, Chinese Academy of Sciences Institute of Psychology, Nanjing University, Nankai University, …

Members (keep growing): Ning Yang, Ye He, Zhe Zhang, Hao-Ming Dong, Lei Zhang, Xing-Ting Zhu, Xiao-Hui Hou, Yin-Shan Wang, Quan Zhou, Zhu-Qing Gong, Li-Zhi Cao, Ping Wang, Yi-Wen Zhang, Dan-Yang Sui, Ting Xu, Gao-Xia Wei, Zhi Yang, Lili Jiang, Hui-Jie Li, Ting-Yong Feng, Antao Chen, Jiang Qiu, Xu Chen, Xun Liu, Ke Zhao, Yi Du, Min Bao, Yuan Zhou, Yan Zhuo, Zhentao Zuo, Li Ke, Chuanjun Zhuo, Fei Wang, Zhi-Xiong Yan, Xue-Quan Su, …

Consultants: F.Xavier Castellanos, Michael Peter Milham, Yu-Feng Zang

Data Sharing

The CCNP data will be publicly shared via the National Science Data Bank and fully available to the research community when acquisition is completed for the pilot CCNP. At this stage, data are only available to researchers and collaborators of CCNP.  Requests for further information and collaboration are encouraged and considered by the CCNP Consortium, and please read the Data Use Agreement and contact us via deepneuro@bnu.edu.cn.

• Imaging Chinese Young Brains (I See Your Brain)
• Brain funtional connectivity matrices for children and adolescents at school age
• Age- and enthinity-specific brain templates and growth charts for children and adolescents at school age

Funding Support

• National Basic Science Data Center `Chinese Data-sharing Warehouse for In-vivo Imaging Brain’ (NBSDC-DB-15)
• National Key Basic Research and Development (973) Program (2015CB351702)
• Major Joint Fund for International Cooperation and Exchange of the Natural Science Foundation of China (81220108014)
• Major Project of National Social Science Foundation of China (14ZDB161, 20&ZD296)
• Chinese Academy of Sciences (CAS) Key Research Program (KSZD-EW-TZ-002), the China – Netherlands CAS-NWO Programme (153111KYSB20160020)
• Beijing Municipal Science and Technology Commission (Z161100002616023, Z171100000117012, Z181100001518003)
• Key-Area Research and Development Program of Guangdong Province (2019B030335001)
• Guangxi BaGui Scholarship (201621)
• Startup Funds for Leading Talents at Beijing Normal University

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